All patients are requested to wear a mask before and during their appointments. Thank you for your cooperation. Learn More about our COVID-19 policies here

You are here

Hand and Elbow Center                 Dr. Luther is a board-certified, fellowship trained Hand and Upper Extremity Surgeon. He earned his BS from the Massachusetts Institute of Technology (MIT) and MD degree from the University of Chicago. He completed his orthopedic surgery residency at Harvard Medical School- training at Massachusetts General Hospital, Brigham & Women's Hospital, Boston Children's Hospital and Beth Israel Deaconess Medical Center. He was a chief resident at Massachusetts General Hospital then went on to pursue a subspecialty fellowship in hand and upper extremity surgery at the Harvard Hand Fellowship in Boston.

Over his career Dr. Luther has published over 20 peer-reviewed papers, several book chapters, and lectured nationally and internationally on hand and upper extremity disorders.  He is the recipient of numerous research and teaching awards and an active member of the American Academy of Orthopaedic Surgeons (AAOS) and American Society for Surgery of the Hand (ASSH). He currently serves on national committees focused on medical education and value-based healthcare delivery. Throughout his career, he has focused on delivering exceptional patient care by combining his interests in education, research and clinical care.

Dr. Luther has a clinical interest in nerve injuries and reconstruction, peripheral nerve surgery, hand and upper extremity fractures, minimally invasive surgery, ligament and tendon disorders, rheumatoid and osteoarthritis, joint replacement, and pediatric hand surgery.  As a collegiate tennis player, Dr. Luther also enjoys caring for athletes with hand and upper extremity injuries, with a focus on early return to play.

His outside interests include value-based healthcare delivery, medical education, health care efficiency and patient-centered quality and outcomes research. In his free time, he enjoys playing tennis, soccer, hiking and traveling the world. He has moved to North Carolina from Boston with his wife, kids and dog and enjoy exploring all that the area has to offer.

Connect with Dr. Luther and Wake Orthopaedics


Provider Type: 
Honors and Awards: 

Jun 2017     Best Clinical Research Award - Harvard Combined Orthopaedics Residency

Jun 2016     Chief Resident - Massachusetts General Hospital/Harvard Combined Orthopaedics Residency

Sep 2015     Clinician Scholar Development Program - America Academy of Orthopaedic Surgeons

May 2015    Resident Teaching Award - Harvard Medical School

Mar 2014    Best Poster Award - Adult Hip Reconstruction, American Academy of Orthopedic Surgeons Conference

Oct 2013      Adrian E. Flatt Resident Research Scholarship- American Society of Surgery for the Hand

May 2012    Leon Jacobson Award for Best Oral Presentation - Senior Scientific Session, University of Chicago Pritzker School of Medicine

Apr 2012     Best Abstract - International Congress for Joint Reconstruction Conference

Feb 2012     Best Oral Presentation - Tumor Society, American Academy of Orthopedic Surgeons

Aug 2011    Fentress Research Fellowship - University of Chicago Pritzker School of Medicine

Mar 2011    Best Basic Science Presentation - Huggins Research Symposium, University of Chicago Pritzker School of Medicine

Mar 2011    Best Clinical Presentation - Huggins Research Symposium, University of Chicago Pritzker School of Medicine

Jun 2010     Pritzker Research Fellowship - University of Chicago Pritzker School of Medicine

Memberships & Publications: 

Ordikhani F., Zandi N., Mazaheri M., Luther G., Ghovvati M., Akbarzadeh A., Annabi N. Targeted Nanomedicines for the Treatment of Bone Disease and Regeneration.  Wiley Online Library.  Dec 2020.  PMID: 33347711

Luther G., Blazar P., Dyer G. Achieving Microsurgical Competency in Orthopedic Residents Utilizing a Self-Directed Microvascular Training Curriculum.  Accepted to JBJS.  Mar 2018

Luther G., Murthy P., Blazar P.  Cost of Immediate Surgery Versus Non-Operative Treatment for Trigger Finger in Diabetic Patients.  Journal of Hand Surgery.  Sep 2016.  PMID: 27671766

Luther G., Miller P., Mahan S., Waters PM., Bae DS.  Decreasing Resource Utilization Using Standardized Clinical Assessment and Management Plans (SCAMPs).  J Pediatric Orthopaedics.  Sep 2016.  PMID: 25887819

Luther G., Lamplot J., Chen X., Rames R., Wagner E., Shen J., Haydon R., He T.C., Luu H.,  IGFBP5 Domains Exert Distinct Inhibitory Effects on the Tumorigenicity and Metastasis of Human Osteosarcoma.  Cancer Letters.  May 2013 PMID: 23665505

Luther G.,  Wagner E., Zhu G., Kang Q., Luo Q., Lamplot J., Bi Y., Luo X., Luo J., Teven C., Shi Q., Kim S., Gao J., Huang E., Rames R., Liu X., Li M., Hu N., Su Y., Chen L., He B.C., Zuo G., Deng Z., Reid R., Luu H., Haydon R., He T.C.  BMP-9 Induced Osteogenic Differentiation of Mesenchymal Stem Cells: Molecular Mechanism and Therapeutic Potential.  Current Gene Therapy.  Mar 2011.  PMID: 21453282

Luther G., Rames R., Wagner E., Zhu G., Luo Q., Bi Y., Kim S., Gao J., Huang E., Yang K., Wang L., Liu X., Li M., Hu N., Su Y., Luo X., Chen L., Luo J., Haydon R., Luu H., Zhou L., He T.C.  Molecular Basis of Differentiation Therapy for Soft Tissue Sarcomas.  Trends in Cancer Research.  Jan 2011

Behzadi S., Luther G., Harris MB., Farokhzad O., Mahmoudi M.,  Nanomedicine for Safe Healing of Bone Trauma: Opportunities and Challenges.  Biomaterials.  Sep 2017

Lamplot J., Luther G., Mawdsley E.L., Luu H.H., Manning D.   Modified Protocol Decreases Surgical Site Infections after Total Knee Arthroplasty.  Journal of Knee Surgery.  Mar 2015.  PMID: 25699629

Lamplot J., Liu B., Zhang W., Wang Z., Luther G., Wagner E., He T.C., Ho S.   Reversibly Immortalized Articular Chondrocytes Acquire Long-Term Proliferative Capability While Retaining Chondrogenic Phenotype.  Cell Transplantation.  Apr 2014.  PMID: 24800751

Chen X., Luther G., Zhang W., Nan G., Wagner E., Liao Z., Haydon R., Zhou L., Luu H., He T.C.   The E-F Hand Calcium-Binding Protein S100A4 Regulates the Proliferation, Survival and Differentiation of Potential of Human Osteosarcoma Cells.  Cellular Physiology and Biochemistry.  Sep 2013.  PMID: 24217649

Hekman K., Aliaga L., Straus D., Luther G., Chen J., Sampat, Frim D.  Positive and Negative Predictors for Good Outcome After Decompressive Surgery for Chiari Malformation Type 1 as Scored on the Chicago Chiari Outcome Scale.  Neurological Research.  Sep 2012.  PMID: 22781921

Aliaga L., Yassari R., Straus D., Hekman K., Luther G., Chen J., Sampat A., Frim D.   A Novel Scoring System for Assessing Chiari Malformation Type 1 Treatment Outcomes.  Neurosurgery.   Mar 2012 PMID: 21849925

Teven C., Liu X., Hu N., Tang N., Kim S., Huang E., Yang Ki., Li M., Gao J., Liu H., Luther G., Luo Q., Wang L., Rames R., Bi Y., Luo J., Luu H., Haydon R., Reid R., He T.C.  Epigenetic Regulation of Mesenchymal Stem Cells: A Focus on Osteogenic and Adipogenic Differentiation.  Stem Cells and Nuclear Reprogramming.   Jul 2011.  PMID: 21772852

Wagner E., Luther G., Zhu G., Luo G., Shi Q., Kim S., Gao J., Huang E., Gao Y., Yang K., Wang L., Teven C., Luo X., Liu X., Li M., Hu N., Su Y., Bi Y., He B.C., Haydon R., Luu H., He T.C.  Defective Osteogenic Differentiation in the Development of Osteosarcoma.  Sarcoma.  Feb 2011.  PMID: 21437219

Pandey S., Luther G., Umanskiy K., Malhotra G., Rubin M., Fichera A.  Minimally Invasive Pouch Surgery for Ulcerative Colitis.  Is there a Benefit in Staging?  Disease of the Colon and Rectum.  Feb 2011.  PMID: 21304301

Rastegar F., Gao J., Shenaq D., Luo Q., Shi Q., Kim S., Jiang W., Wagner E., Huang E., Gao Y., Shen J., Yang K., He B.C., Chen L., Zuo G., Luo J., Luo X., Bi Y., Liu X., Li M., Nu N., Wang L., Luther G., Luu H., Haydon R., He T.C.  Lysophosphatidic Acid Acyltransferase b (LPAATb) Promotes Tumor Growth of Human Osteosarcoma.  PLoS ONE.  Dec 2010.  PMID: 21152068

He B.C., Gao J., Zhang B., Luo Q., Shi Q., Kim S., Huang E., Gao Y., Yang K., Wagner E., Wang L., Tang N., Luo J., Liu X., Li M., Bi., Shen J., Luther G., Hu N., Zhou Q., Luu H., Haydon R., Zhao Y., He T.C.  Tetrandrine Inhibits Wnt/B-Catenin Signaling and Suppresses Tumor Growth of Human Colorectal Cancer.  Molecular Pharmacology.  Oct 2010.  PMID: 20978119

Teply B., Tong R., Jeong S., Luther G., Sherifi I., Yim C., Khademhosseini A., Farokhzad O., Langer R., Cheng J.  The Use of Charge-Coupled Polymeric Microparticles and Micromagnets for Modulating the Bioavailability of Orally Delivered Macromolecules.  Biomaterials.  Dec 2007.  PMID: 18082254

Cheng J., Teply B., Sherifi I., Sung J., Luther G., Gu F., Nissenbaum E., Moreno A., Langer R., Farokhzad O.  Formulation of Functionalized PLGA-PEG Nanoparticles for in Vivo Targeted Drug Delivery.  Biomaterials.  Feb 2007.  PMID: 17055572


"Could not speak more highly of Dr. Luther and everyone I met in the offices in which he works.  Broke a finger and dislocated another.  He put me back together.  Dr. L was super pleasant each time I met with him.  Could not have bee a nicer guy.  I saw him at 4 different offices and in each one, his office staff was a pleasure to work with and seemed to genuinely have fun with one another.  To me this is a sign of a well run office.  I especially want to call out Debbie L., his Medical Assistant and Colleen, the OT at the Apex office.  Debbie is competent, gives you contact information and responds when you reach out.  She is also so much fun.  Colleen is a gem.  She is pleasure to work with and a gifted OT."

"Dr. Luther is amazing!  Took excellent care of our son.  From the first appointment to the day of surgery.  He was open and honest with what results could be and never pressured us, let us make the decision through open and honest discussions.  Has an amazing way with patients to put them (and parents, son was 12) at ease.  He is an extraordinary doctor and a talented surgeon and Wake Ortho is lucky to have him on their staff!"

"Very happy with the care I received from Dr. Luther.  He is professional but also friendly.  He took his time with me and seemed genuinely concerned that all my questions were answered.  he also did a great job with the surgery on my wrist.  I received wonderful care and recommend him highly."

"Dr. Luther did an excellent job on my ulnar nerve repositioning surgery and at estimating my recovery time, he is also friendly and great at explaining things."

"Dr. Luther repaired my injured finger involving reattaching severed tendons.  My finger is almost completely healed now with full use of movement.  He is a very skilled surgeon, knowledgeable, and explains the procedure and process very well.  He also had prescribed physical therapy steps versus "standard steps" that impressed the therapist in its approach to recovery."

"I have been very happy with the exceptional service I received from Doctor Luther.  I had an accident two months back and there was multiple fractures on left hand and wrist.  He performed surgery on me at the hospital and I have visited him a few time for post surgery follow up.  He explains the situation extremely well with positive outlook.  My wrist and hand have recovered quite a bit and they will heal in next couple of months.  I will recommend him to anyone needing surgery and care."

"I cut my nerve and broke 2 bones after a motorcycle accident 3 months ago and saw Dr. Luther.  He not only repaired my fractures and nerve, but started me in an early rehab to get my motion and strength back.  I never thought it'd be possible, but I was able to start playing guitar again.  I cannot thank him enough.  His staff is great and Debbie his assistant is fantastic.  I would recommend him hands down and feel lucky to have seen him."

"Most caring doctor I've seen!  I had wrist arthritis from an accident I was told needed to be fused.  He saw me and offered another option for pain relief by removing some of the painful nerves, and now after surgery, I feel almost 100% and can still move my wrist.  Not only that, he called me before and after surgery to check on me, always was extremely caring and explained everything in detail.  I've never had a doctor (and especially a surgeon) take this much time out for a patient.  Extremely grateful!"

"After being referred to Dr. Luther by my PCP with suspected carpal tunnel syndrome, based on my description of my nerve pain/numbness and an ultrasound, Dr. Luther confirmed carpal tunnel and recommended corrective surgery, which I opted for.  Dr. Luther and all the staff were excellent.  He was 100% professional and his "bedside manner" was awesome.  The surgery was as routine as "routine surgery" can be, IMO.  After today's 2-week follow-up, he has cleared me for full use of my left hand/wrist.  I would highly recommend him if carpal tunnel syndrome surgery is something you feel you need!"

"Dr. Luther has been my surgeon for 3, and eventually 4, surgeries.  I originally saw him for a very severe radius fracture in October of 2018.  During the whole process he was incredibly kind and thorough.  He tried to convey the seriousness of the injury while being positive about the out come.  I felt confident that I was making the right choice in having surgery.  He even told me that if I felt like I needed a second or third opinion he could give me some names of other surgeons.  The staff surrounding him (especially Debbie) at Wake orthopaedics Cary, Apex and Garner locations, where also incredible.  I literally cannot say enough good things about him."

"Dr. Luther saw my son for his thumbs.  He was born with congenital thumbs that were smaller and more unstable than normal.  As a parent, all you can do is worry - but after meeting Dr. Luther I could not have felt more comfortable.  he explained everything, even referred us to the proper pediatricians for genetic testing and eventually proceeded to reconstruct the right thumb.  My son is now using his hands like never before - I could not be more grateful.  We are planning on having the other side done in a few months."

"Really nice doc, never rushed.  He really seems to love orthopedics and explained the mechanics of the hand to me, even though he didn't need to.  Oh, and it doesn't hurt that hes from Harvard....great guy."

"Very good experience - staff and his assistant Debbie are great, and Dr. Luther is a very kind doctor."

"I tore the ulna collateral ligament on my thumb back in August 2018 during a fall but didn't see Dr. Luther until March 2019.  At the time, my thumb was so unstable that I couldn't even hold a cup of coffee.  Dr. Luther not only assisted with the X-ray of my hand but took the time to explain the damage, what could be done surgically and the possible outcomes I could expect afterwards.  He is a highly skilled surgeon with a super personality who truly cares about his patients.  From the surgery to the physical therapy, he and his entire staff (especially Debbie & Jennifer) at Wake Orthopaedics of Garner made the experience as pleasant as possible!"

"Fantastic experience with Dr. Luther, Debbie and their team.  I was treated for scaphoid ligament tear after a rugby injury.  He did a great job and I only took a few Tylenols after surgery.  The therapy team really pushed me to a speedy recovery.  Id highly recommend him and his entire staff, a great team!"

"Dr Luther performed the 2nd surgery on my wrist and hand to repair damage from a previous surgery caused by a severe break and repair nerve damage.  He is one of the kindest and most caring doctors I have encountered, and an outstanding surgeon.  I would high recommend Dr. Luther."